What is CBG?

What does CBG mean? Cannabigerol! It is a cannabinoid found in cannabis. CBG what is it? It is one of many minor cannabinoids and mature cannabis plants typically contain less than 1% CBG. CBG has been found to not produce any psychoactive effects, similar to CBD. People are using CBG for a variety of different purposes, including neurodegenerative diseases, inflammatory bowel disease, and infections.

What is CBG in Weed?

What is CBG in cannabis? Hemp and marijuana are the same species of plant: Cannabis sativa L. Scientifically, there is no difference between the two. Legally, the difference comes down to THC content.

Ernest Small, in his 1979 book titled “The Species Problem in Cannabis: Science & Semantics,” notes that there is no classification difference between hemp and marijuana and proposed 0.3% THC as a possible solution to the classification dilemma. He acknowledges 0.3% is an arbitrary number.

CBG in the Hemp Plant

Hemp plants contain 0.3% or less tetrahydrocannabinol, or the psychoactive compound THC, which is the cannabinoid known for its “high” effects. Due to the small concentration of THC, it is unlikely for hemp to produce impairment. What is CBG in hemp? CBG products derived from hemp typically will not contain more than 0.3% THC. What is hemp CBG? It is CBG derived from hemp plants!

CBG in the Marijuana Plant

So what is CBG in weed? Marijuana, or weed, while still being a cannabis plant, contains more THC than hemp. Any cannabis plant containing more than 0.3% THC is legally classified as marijuana. Marijuana typically contains enough THC to produce a “high” effect. Marijuana derived CBG products are likely to have a higher concentration of THC. For those who want the benefits of CBG without psychoactive effects, hemp derived CBG products may be a better option.

What is CBG Cannabinoid?

What is a CBG before it is CBG? It’s CBGA! The precursor to CBG is CBGA, which is the acidic form of CBG. CBGA is known as “The Mother of All Cannabinoids,” because CBG is what all other cannabinoids start out as!

Acidic Cannabinoids

Young cannabis plants produce CBGA which gets broken down by naturally occurring enzymes into other acidic cannabinoids, including CBDA, THCA, and CBCA. These cannabinoids then go through a process called decarboxylation, either by aging or heat, which is the removal of a carbon atom from a carbon chain. CBG what is it? It’s decarboxylated CBGA!

Decarboxylation

Decarboxylation converts cannabinoids into their “activated” forms. Therefore CBDA converts into CBD, THCA into THC, CBCA into CBC, and CBGA into CBG. Acidic, or non-activated cannabinoids, do not produce psychoactive effects when taken by themselves. It is theorized that including acidic cannabinoids with activated cannabinoids may contribute to the entourage effect, which is the idea that the additional cannabinoids boost the effectiveness of each other and increase synergy.

What is a CBG

What is a CBG?

What is CBG cannabinoid? We wouldn’t be able to benefit from any cannabinoids if human bodies weren’t already equipped with an endocannabinoid system that can use them. The endocannabinoid system is a biological system believed to play a part in regulating many functions of the human body, such as appetite, memory, mood, sleep, and pain.

The Body's Endocannabinoid System

The endocannabinoid system is essential in helping the cells within our body maintain homeostasis, or keeping conditions optimal for our cells to perform at their best. It is made up of cannabinoid receptors, metabolic enzymes, and endogenous cannabinoids, meaning cannabinoids produced within the body. These are often referred to as endocannabinoids.

CBG What is it

CBG What is it?

Health Benefits

What is CBG oil and how does it affect people? What is CBG medical applications? What is CBG mean for people dealing with the following? Here are some studies done regarding what is CBG cannabinoid and the effects researchers observed during the studies. While more research is needed to determine the complete effects of CBG, studies have shown promising results.

Intraocular Pressure

What is the CBG effect on intraocular pressure? A study from 1984 tested the administration of CBN and CBG on animal subjects and monitored intraocular pressure. CBN had a small effect after a single dose, and reduced ocular tension more significantly during extended administration. Compared to CBN, CBG had effects that were similar after a single dose, but the response to its recurring application was greater than that of the CBN.

CBN also caused conjunctival erythema, or inflammation of the eye, and hyperemia, which is dilation and redness of the blood vessels in the conjunctiva. The conjunctiva is the tissue that covers the outer surface of the eye and the inside of the eyelid. CBG did not cause the same negative reaction

The results of this study indicated that both CBG and CBN have the potential to lower ocular tension considerably with chronic administration. CBG did not show signs of damaging the nervous system or affecting the structure or function of the eye, it seems the ability for CBG to lower pressure in the eye is able to be separated from the negative central nervous system and ocular effects that accompany cannabis intake. What is CBG in weed? Weed, or marijuana, contains THC and CBN, with the potential to damage the nervous system or affect the structure of the eye. What is CBG hemp? CBG hemp has lower amounts of THC and CBD, thus may be able to lower the possibility of negative effects from THC and CBD.

Neurodegenerative Diseases

What is a CBG product potentially able to do for neurodegenerative diseases? According to the Huntington’s Disease Society of America, Huntington’s Disease is a genetic disease of the brain caused by a very small error in only one gene, which is referred to as the huntingtin gene. This irregularity can lead to brain damage and cause symptoms of Huntington’s Disease, such as changes in mood and personality, issues with memory and judgment, uncontrollable movements called chorea, and slurred speech.

As of right now, cures or treatments do not exist. A 2014 study on the neuroprotective properties of CBG in Huntington’s Disease discovered that treatment with CBG resulted in being a strong neuroprotectant in mice by preserving neurons responsible for learning and memory and improved on deteriorated motor coordination. There is hope that in the future CBG could be used as a neuroprotective compound.

Neurodegenerative Diseases

Inflammatory Bowel Disease

It was estimated in 2015 that 3.1 million United States adults have been diagnosed with having inflammatory bowel disease, or IBD. Crohn’s disease and ulcerative colitis are the two types of inflammatory bowel disease. These diseases consist of gastrointestinal tract inflammation and symptoms include repeated diarrhea, pain in the abdominal region, blood in stools, lack of energy, and unexpected weight loss.

A 2013 study on bowel inflammation in rodents showed reduced inflammation in the gastrointestinal tract and less production of nitric oxide in intestinal macrophages with CBG treatment, which is a gas involved in the development of gastrointestinal diseases. CBG showed to be beneficial in this study of experimental inflammatory bowel disease, and researchers suggested it be “considered for clinical experimentation in IBD patients.”

Bladder Dysfunctions

In the United States, thirty percent of men and forty percent of women suffer from an overactive bladder. Having an overactive bladder consists of a strong and sudden need to urinate that is impossible to ignore. When the bladder is full, the brain tells the bladder muscles to contract. Acetylcholine is the main neurotransmitter responsible for communicating this with the bladder.

A 2015 study on phytocannabinoids and their effect on bladder contractions showed that CBG lowered the amount of bladder contractions caused by acetylcholine in the human bladder. This showed researchers that CBG has the potential to decrease urgency to urinate.

Tumor Growth

According to a 2014 study investigating whether CBG can protect against the production or formation of colon tumors, it is stated that CBG interacts with targets involved in the initiation of cancer formation. The effects of CBG were gauged using mouse models of colon cancer.

Tumor Growth

It was found that CBG promoted apoptosis, or the normal and controlled death of cells that occurs as part of an organism’s development. CBG was also shown to stimulate reactive oxygen species, or ROS, production. In moderate levels, ROS can lead to cell damage, DNA mutation, and inflammation, which furthers the start and development of cancer. But in extremely high levels, ROS causes cancer cell death.

In this study, CBG was also shown to reduce cell growth in colorectal cancer cells. Researchers concluded the abstract of this study by saying CBG should be considered in colorectal cancer cell prevention.

Appetite Stimulant

Many factors can lead to a person having a loss of appetite. Bacteria, viruses, mental health disorders, cancer, heart disease, lung disease, and even a common cold are all reasons a person may not have the desire to eat. If a person refrains from eating enough food for too long it can lead to undesired consequences, such as weight loss, fatigue, and malnutrition.

For many centuries, it has been documented that cannabis has the potential to increase cravings for food. But what about the people who are suffering from lack of appetite and don’t want to experience the psychoactive properties? This might be where CBG comes into play.

Appetite Stimulant

In 2016, a study was done on cannabigerol CBG and food intake in rats. During the study, fine motor coordination was not detrimentally affected and CBG was able to stimulate appetite in previously-fed rats. The study concluded that the resulting data indicated reason for preclinical exploration of CBG as treatment for cachexia caused by cancer or chemotherapy.

Cachexia is a loss of body weight and muscle mass, often accompanied by weakness, that tends to affect people with illnesses such as cancer, AIDS, and other chronic diseases. There exists the need for a well-tolerated appetite stimulant that researchers are hoping CBG can eventually fill.

Bacterial Infections

CBG has shown potential to fight drug resistant staph infections. Staph, or Staphylococcus aureus, is a type of bacteria frequently found on the skin. While usually they are harmless bacteria, it is possible for them to cause infections that are very serious.

Staph is the bacteria responsible for MRSA, or methicillin-resistant Staphylococcus aureus. MRSA can cause skin infections, pneumonia, or other infections. MRSA can lead to sepsis, which is when the body’s immune system reacts to an infection and begins attacking its own healthy tissues, if it remains untreated.

In 2020, a study found CBG to have antibacterial properties and also be effective against MRSA in mice. Eric Brown, who is a professor of biochemistry and biomedical sciences at McMaster University and one of the researchers, said that, “the findings suggest real therapeutic potential for cannabinoids as antibiotics.”

What is CBG Oil?

There are a handful of ways to incorporate CBG into a daily regimen. CBG is available as a CBG isolate powder, CBG oil, also called cannabigerol oil, and in trace amounts in full- and broad-spectrum CBD products. What is CBG oil? It is an oil that contains only CBG isolated from other components in the plant.

What is CBG Oil

Full Spectrum vs Broad Spectrum vs Isolate

Full spectrum products are made using the entirety of the hemp extract and include trace amounts of THC and other cannabinoids and terpenes found within the plant. Terpenes are compounds that give plants, including cannabis, oranges, eucalyptus, and others, their specific aroma. Research indicates that terpenes can also increase the entourage effect.

Broad spectrum products are made very similarly to full spectrum products. The difference is that broad spectrum products are made using extract that has gone through an additional process called chromatography, which is used to remove the THC from the plant extract.

Isolate products are made using only CBG and no other components from the plant. These products are often preferred by people with any drug testing concerns, as there are no other components from the plant within the product.

Full Spectrum vs Broad Spectrum vs Isolate

Methods of Consumption

When using products like CBG isolate powder, many people are adding the powder to a carrier oil, such as olive oil, and using it sublingually. Sublingual application involves a person putting oil under their tongue and holding it for 30 seconds to a minute, then swallowing it. This gives the CBG time to absorb in the tiny blood vessels under the tongue, usually taking effect within 15 to 20 minutes. People find that using their CBG oil this way results in it lasting 4 to 6 hours.

Water soluble CBG tinctures, or even full- or broad-spectrum tinctures that are water soluble that contain trace amounts of CBG, are often being mixed into drinks such as water or tea and being ingested in addition to being used sublingually. Most people find that this method takes effect in 30 to 90 minutes and results last them 8 to 10 hours.

What is CBG cannabis? What is CBG hemp? CBG hemp is hemp flower typically harvested from young hemp plants for its high concentrations of CBG. When inhaled, people usually find the effects kick in within minutes, but only last a few hours. What is CBG weed? And what is CBG marijuana? It is flower harvested from marijuana plants that contains higher amounts of THC than hemp.

History of CBG

Cannabigerol or CBG is a minor cannabinoid that was discovered along with CBD and THC in the 1960s. CBG is a rare cannabinoid, most mature medical cannabis and hemp plants contain less than 1% of CBG. CBG is non-psychoactive. Much like its cannabinoid brother, CBD, it does not produce any effects of euphoria.  As more money goes into researching cannabinoids, more people have started studying CBG and are seeing promising results of the medical benefits of CBG.  We are just beginning to understand all the potential that CBG has to offer.

cbg chemical formula

1964:

CBG is discovered to be present in varieties of cannabis particularly in budding and immature flowers. This year also marks the discovery of an endocannabinoid system in humans that interacted specifically with cannabinoids found in plants.

1975:

CBGA (the acidic version of CBG) is isolated in the cannabis plant. Studies show that CBGA is the biological origin of all other cannabinoids in cannabis including THC, CBD, CBN, CBC and THCv. The acidic version of CBG is then nicknamed “The Mother of All Cannabinoids”.

1990:

This was the first official study of the effects of CBG. The study focused on the effects of CBG on those suffering from glaucoma. The study saw promising results with intraocular pressure being greatly reduced. They also saw an increase in aqueous flow by two to three times what is was without the CBG treatment.

2007:

Despite the promising results of CBG on glaucoma, another study wouldn’t be done on CBG for another 17 years. In 2007, two UK universities conducted two separate studies on CBG. One study focused on CBGs ability to aid in bone growth. The study concluded that CBGs positive interaction with the CB2 receptors helped bones grown faster and stronger. The other study looked at the potential for CBG to aid in a variety of skin conditions. The study focused on CBGs interaction with our skin when applied topically. The study concluded that not only did we have an abundance of CB2 receptors on our skin, but that CBG inhibits keratinocyte proliferation making it a possible solution for those who suffer from severe skin conditions.

2008:

Perhaps due to the promising results of the studies of CBG on skin issues or due to the interest of CB2 receptors being so present in our skin, a study was conducted on CBG and its potential as a powerful Anti-fungal. However, CBG was shown to be highly effective against fungal skin conditions.

2009:

A review article done in 2009 by a combination of Italian and Israeli research centers, suggested that CBG had a directly positive impact on decreasing the size of tumors and could potentially aid in extending the life of those dealing tumors. The review concluded that CBG was an anti-proliferative and worked better than other cannabinoids in reducing the size of cancerous tumors.

2015:

A research group in Spain focused on neurological conditions started to consider CBG in their treatments. While the studies that they did were focused on animal trials only, they recommended that CBG be used in a variety of neurological treatments and considered it to be a very powerful for neuroprotection. That same year, another study would conclude that CBG was also a promising treatment for an over-active bladder.   

2016:

The most recent study was done just last year. They focused on the effect of CBG for those dealing with chronic stress. Since it is non-psychoactive, you wouldn’t feel the paranoia that can sometimes accompany taking high amounts of THC. The study concluded that CBG worked just as well as THC for aiding those suffering from high stress without any of the psychoactive effects. CBG is suggested to be better than THC because CBG directly effects the CB2 receptors instead of just the CB1 receptors in your endocannabinoid system.

 

Where to get CBG?

Small amounts of CBG are available in some of our products already. We use whole plant extraction to preserve an entourage effect of a variety of cannabinoids in our Active CBD Products. The Entourage Effect refers to the potential of health benefits by combining cannabinoids together. 

Isolated CBG - This isolated form is very similar to our 99% Pure CBD Isolate and has the potential to be used in a variety of ways including vaping, topicals and edibles. 

 

Isolated CBG

 

 Water Soluble CBG Tinctures - CBG tinctures are easy to take directly under the tongue or mixed into a beverage. 

 

water soluble CBG Tincture

 

 Do you have a question or comment about CBD, CBG or any of our products? Let us know, and we will respond right away. In the meantime, sign up for our newsletters and visit our website DiscoverCBD.com regularly for the latest updates on research, legislation, and other news impacting you and cannabidiol.

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