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What Can Enhance the Effects of Cannabidiol?

Posted by Seth B on

Many people who have been satisfied with the outcomes of daily cannabidiol (CBD) supplementation have wondered whether it is possible to enhance one of the benefits they report, while still keeping their overall CBD product intake consistent. For example, someone may feel that CBD has helped them feel more motivated; therefore, they are happy with their daily regimen of CBD oil–infused tea, but they would like additional relief from arthritis symptoms.

Currently, the main way to address this problem is to try different types of supplements. For instance, the person who wants help with their arthritis may find better results from a topical package, such as a recovery cream. Various supplements can change the timing of CBD absorption, may offer local versus global effects, or may be packaged with ingredients such as peppermint oil which is intended to enhance the potential benefits of CBD. However, researchers worldwide are also studying different ways to potentiate, or strengthen, specific effects of CBD in animal and cellular models.

The research that has been done is in the experimental phase, and should not be replicated outside of a laboratory until the effects of these different compounds have been thoroughly studied in human beings. In other words, don't try the following studies at home!

One potential method of improving CBD delivery is to package it in another molecule that can be swiftly absorbed into the body. Most CBD products already work fairly quickly, but for migraines or other acute problems, researchers want to develop ways to deliver CBD nearly instantaneously. Think of it as sending the CBD to the body by overnight mail, instead of priority mail.

Cherniakov et al. developed a compound called a pro-nanoliposphere (PNL), which was basically a combination of fatty molecules known as lipids, and piperine, the molecule responsible for the spicy taste of pepper. When CBD was added to the PNL and given to rats in an edible form, Cherniakov et al. found that the blood levels of CBD were six times greater than when the rats had consumed other types of CBD-lipid compounds. Of course, CBD products with PNLs won't be on the market anytime soon as much more research is required before they could be used in products, but it is exciting to know that there are possibilities like this.

Other researchers like Scott et al. have considered adding other compounds into CBD preparations. To some extent, this approach is already used in products like Active CBD oil who already do this by combining hemp oil and CBD in a single capsule. However, Scott et al. examined combinations of CBD and active drugs, including psychoactive cannabinoids. They found that applying CBD and cannabigerolic acid (CBGA) to cancer cells resulted in amplified anti-tumor effects compared to using either CBD or CBGA alone. Likewise, combining CBD with cannabigerovarin (CBGV) and CBGV acid were found to be more effective than any of the cannabinoids alone in preventing the growth of breast cancer cells in a cell sample.

So what does this all mean for someone interested in CBD, or who already uses it in a daily regimen? For the time being, people who would like to enhance certain effects of CBD can try different packages of CBD or make use of products that contain CBD alongside other compounds. The research that is being done on enhancing CBD, however, seems to indicate that at some point in the future, we will see entirely novel CBD delivery systems tailored to different supplemental needs. If you are interested in CBD as a daily supplement, you don't need to wait for these advanced systems to be designed. You may find that, among the vast amount of CBD products that are currently available like tinctures, dabs, and topicals, there might be several options that can deliver just what you are looking for.

Do you have a question or comment about CBD? Let us know, and we will respond right away. In the meantime, sign up for our newsletters and visit our website regularly for the latest updates on research, legislation, and other news impacting you and cannabidiol.

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